Cathepsin B, H and L inhibitors as cell proliferating agents: design, synthesis, computational and pharmacological studies of some novel 2-(2-naphthoyl)-6,6-dimethyl-3-aryl-2,3,6,7-tetrahydrobenzofuran-4(5H)-ones

A novel series of 2-(2-naphthoyl)-6,6-dimethyl-3-aryl-2,3,6,7-tetrahydrobenzofuran-4(5 H )-one derivatives synthesized and structure confirmed by X-ray crystallography have been evaluated as inhibitors to cathepsins B, H and L as well as cell proliferating agents.