Key result
A single cycle of plasmapheresis in a patient with severe hypertriglyceridemia-induced acute pancreatitis resulted in an 83% reduction in triglyceride levels and rapid clinical resolution.
Why the study?
Clinical evidence is relatively weak regarding the use of plasmapheresis for the treatment of hypertriglyceridemia-induced acute pancreatitis.
Does plasmapheresis improve symptoms and reduce triglyceride levels in a patient with severe hypertriglyceridemia-induced acute pancreatitis?
Case Report (n=1)
No
Does plasmapheresis improve symptoms and reduce triglyceride levels in a patient with severe hypertriglyceridemia-induced acute pancreatitis?
Plasmapheresis may be a highly efficacious option for rapidly reducing triglyceride levels and improving clinical symptoms in severe hypertriglyceridemia-induced acute pancreatitis.
May support plasmapheresis in refractory hypertriglyceridemia pancreatitis; hypothesis-generating, requiring RCTs before practice change.
Hypertriglyceridemia is the third most common etiology for acute pancreatitis (AP), after alcohol and gallstones. Clinical evidence is relatively weak in its support of plasmapheresis for the treatment of hypertriglyceridemia-induced acute pancreatitis (HTG-AP). We report a case of severe HTG-AP in a young man who was successfully treated with plasmapheresis. The patient achieved full resolution of symptoms within 48 hours from presentation and was discharged two days later. To our knowledge, no other report in literatures shows such dramatic response to plasmapheresis.
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Kenne et al. (2020) conducted a case report in Hypertriglyceridemia-induced acute pancreatitis (n=1). Plasmapheresis was evaluated on Triglyceride level reduction. A single cycle of plasmapheresis in a patient with severe hypertriglyceridemia-induced acute pancreatitis resulted in an 83% reduction in triglyceride levels and rapid clinical resolution.
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