Key result
While FGF-23 levels were higher in hemodialysis patients with increased carotid intima media thickness, FGF-23 was not a significant independent predictor of increased cIMT on regression analysis.
Why the study?
Altered mineral metabolism correlates with cardiovascular risk in CKD, prompting the hypothesis that serum FGF-23 may independently correlate with cardiovascular risk factors.
Does plasma FGF-23 level correlate with carotid intima media thickness in patients on hemodialysis?
Cross-Sectional (n=100)
No
Does plasma FGF-23 level correlate with carotid intima media thickness in patients on hemodialysis?
Background: One of most prevalent cause of death in patients on hemodialysis (HD) is cardiovascular disease (CVD). Cardiovascular events in HD patients are significantly predicted by ultrasound measurements of carotid intima media thickness (cIMT). The hypothesis that serum fibroblast growth factor-23 (FGF-23) may be independently correlated with cardiovascular risk factor has been suggested because of the substantial correlation between altered mineral metabolism and increased cardiovascular risk in patients with chronic kidney disease (CKD). This study's objective was to assess the plasma FGF-23 level and its correlation to cIMT in patients with kidney failure on HD. Methods: 100 participants on regular HD participated in the study. Two groups of patients were created based on cIMT; group 1 consisted of 50 participants with increased cIMT 1 mm, and group 2 consisted of 50 participants with cIMT below 1 mm. Patients with diabetes mellitus, patients on anticoagulant therapy and those with history of parathyroidectomy were excluded from the study. High resolution B-mode ultrasonography was utilized to evaluate cIMT at the common carotid artery.
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A 2023 study conducted a cross-sectional in Hemodialysis (End-Stage Renal Disease) (n=100). Fibroblast Growth Factor-23 (FGF-23) level vs. Patients with cIMT < 1 mm was evaluated on FGF-23 level in patients with cIMT ≥ 1 mm vs cIMT < 1 mm (p=0.001). While FGF-23 levels were higher in hemodialysis patients with increased carotid intima media thickness, FGF-23 was not a significant independent predictor of increased cIMT on regression analysis.
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