Key result
Elevated serum FGF-23 levels were significantly correlated with increased carotid intima-media thickness in patients with early-stage chronic kidney disease (p=0.01).
Why the study?
FGF-23 correlates with cardiovascular morbidity and mortality, but its relation with carotid intima-media thickness in early-stage CKD needed evaluation.
Observational (n=360)
Yes
p-value: p=0.01
Elevated FGF-23 levels strongly correlate with increased carotid intima-media thickness in early CKD, suggesting it may serve as a predictor for subclinical atherosclerosis.
May inform CV risk stratification in nondiabetic CKD; leaves open whether FGF-23 is causal or actionable.
between July 2017 to August 2019 by prospectively observing a cohort of 270 CKD cases that had been reported during this period. After ruling-out diabetes mellitus and pre-existing cardio-vascular or cerebro-vascular conditions, these 270 CKD cases were enrolled from amongst the regular out-patients visiting the ABSTRACT Background: FGF-23 regulates phosphate homeostasis and has a correlation with morbidity and mortality due to cardiovascular episodes and chronic renal conditions. The risk of subclinical atherosclerosis can be predicted by measurements of the intima-media thickness of the carotid artery. The objective of this studyisto study therelation between serum FGF-23 levels and Carotid intima-media thickness in the early stages of CKD. Materials and Methods: This study was conducted at MLN Medical College, SRN Hospital, Prayagraj and Tejas Microdiagnostics. The study design adopted was prospective and observational. A total of 270 newly diagnosed CKD patients were enrolled as cases while 90 patients without CKD were taken as control. Highresolution ultrasonography was utilised to measure Carotid artery intima-media thickening. Serum FGF-23 levels were performed at the beginning of study, along with other baseline investigations and were repeated on 6 th and 9 th months respectively. Results: Among the case group of CKD, the mean age was 54.8+2.1 years with male to female proportions representing 62% and 38%, respectively of the control group consisted mean age distribution of 51.0 + 2.1 years a and male-female proportion of 58% and 42%, respectively. It was observed that FGF-23 levels and Carotid intima-media thickness measurements were high in patients than in controls. A statistically significant correlation at 0.01 levels was observed between FGF-23 and the Carotid intima-media thickness. Conclusion: Our study clearly establishes a strong correlation between FGF-23 and CIMT indicating that FGF-23 plays an important role in the development of vascular calcifications in early stages of CKD. Subclinical atherosclerosis in CKD patients can be predicted by monitoring of their FGF-23 and CIMT level.
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Narain et al. (2023) conducted an observational in Chronic Kidney Disease (CKD) (n=360). Elevated serum FGF-23 levels vs. Patients without CKD was evaluated on Correlation between serum FGF-23 levels and Carotid intima-media thickness (p=0.01). Elevated serum FGF-23 levels were significantly correlated with increased carotid intima-media thickness in patients with early-stage chronic kidney disease (p=0.01).
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