Key result
Carotid intima media thickness was significantly higher in patients with stage 4 and 5 chronic kidney disease (0.9 mm) compared to stage 3 (0.8 mm, p<0.001).
Why the study?
CKD is a significant prognosticator of cardiovascular disease, and atherosclerosis is common in patients with risk factors associated with chronic kidney disease.
Cross-Sectional (n=90)
No
Absolute Event Rate: 0.9% vs 0.8%
p-value: p=<0.001
CIMT is significantly increased in advanced CKD and correlates with diabetes and elevated phosphorus, supporting its use as a non-invasive marker for atherosclerosis risk in this population.
Background: Chronic kidney disease is distinguished by progressive loss of kidney function over a period of years in the end leading to irreversible kidney failure. CKD is a significant prognosticator of cardiovascular disease. Atherosclerosis is common in patients with risk factors associated with chronic kidney disease.Methods: It was a cross sectional study on CKD patients in a tertiary care hospital. About 90 CKD stage 3-5 patients aged above 18 years were enrolled in the study. Serum lipid profile, RFT, serum calcium, phosphorous, and BP were estimated among all the patient. Patient risk factors were noted and CIMT levels were compared accordingly.Results: Out of 90 patients, males were predominant. There was a significant positive correlation between stage 5 and CIMT (P value <0.001). Mean CIMT was higher in patients with type 2 Diabetes. Patients with higher phosphorous the mean CIMT was significantly higher.Conclusions: The CIMT is early marker for atherosclerosis. Author observed it was significantly higher in patients with stage 3 and 5 CKD. CIMT is a non- invasive marker which should be done in all patients with CKD which is cost effective.
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Srikanth et al. (2019) conducted a cross-sectional in Chronic kidney disease (n=90). Advanced chronic kidney disease (Stage 4-5) vs. Stage 3 chronic kidney disease was evaluated on Right Carotid Intima Media Thickness (CIMT) in mm (p=<0.001). Carotid intima media thickness was significantly higher in patients with stage 4 and 5 chronic kidney disease (0.9 mm) compared to stage 3 (0.8 mm, p<0.001).
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