Key result
Mean carotid intima-media thickness was significantly higher in patients with chronic kidney disease compared to age- and sex-matched controls (0.89 vs 0.50 mm; P<0.001).
Why the study?
CKD patients face increased cardiovascular disease risk, prompting investigation into correlates of carotid intima-media thickness as a non-invasive marker of subclinical atherosclerosis.
Is carotid intima-media thickness increased in Nigerian adults with chronic kidney disease compared to controls, and what are its correlates?
Cross-Sectional (n=315)
No
Is carotid intima-media thickness increased in Nigerian adults with chronic kidney disease compared to controls, and what are its correlates?
Absolute Event Rate: 0.89% vs 0.5%
p-value: p=<0.001
CIMT is significantly increased in Nigerian patients with CKD and correlates with multiple traditional and non-traditional cardiovascular risk factors, highlighting its utility for early subclinical atherosclerosis detection.
CIMT correlates may aid CV risk stratification in CKD; leaves open whether measurement improves outcomes in prospective studies.
Background: Chronic kidney disease (CKD) patients are at an increased risk of cardiovascular disease. Carotid intima-media thickness (CIMT) is a non-invasive marker of subclinical atherosclerosis and a useful tool for cardiovascular risk assessment. This study investigated the correlates of CIMT among CKD patients at Jos University Teaching Hospital. Materials and Methods: A cross-sectional analytical study was conducted among 189 CKD patients and 126 age- and sex-matched controls. Eligible participants were recruited consecutively. Clinical evaluation, laboratory investigations and CIMT measurements were performed. Data were analysed using Epi Info version 7, with P value < 0.05 considered significant Results: Mean age was similar among CKD patients and controls (47.02 ± 13.63 vs 47.66 ± 13.84 years; P = 0.684). Mean CIMT was significantly higher in CKD patients than among controls (0.89 ± 0.20 vs 0.50 ± 0.01 mm; P < 0.001). Increased CIMT was observed in 28.6% of CKD patients, while 10.1% had atheromatous plaques. Independent correlates of increased CIMT included advancing age, diabetes, systolic and diastolic hypertension, increased waist circumference in males, increased urine protein creatinine ratio, reduced estimated glomerular filtration rate, low haemoglobin, elevated serum phosphate, increased calcium–phosphate product, elevated total cholesterol and low-density lipoprotein cholesterol, increased cardiothoracic ratio and higher uric acid levels. Conclusion: Increased CIMT is common in CKD and associated with multiple cardiovascular risk factors. CIMT is a valuable tool for early detection of subclinical atherosclerosis and cardiovascular risk stratification.
No takes yet. Share an insight, caveat, or question.
Uchendu et al. (2026) conducted a cross-sectional in Chronic Kidney Disease (n=315). Chronic kidney disease vs. Age- and sex-matched controls was evaluated on Mean carotid intima-media thickness (CIMT) (p=<0.001). Mean carotid intima-media thickness was significantly higher in patients with chronic kidney disease compared to age- and sex-matched controls (0.89 vs 0.50 mm; P<0.001).
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: