What question did this study set out to answer?

To compare the efficacy of simple versus intensive postoperative surveillance strategies on overall survival and recurrence resectability in patients with resected colorectal cancer.

December 20, 2005Journal of Clinical Oncology

Postoperative Surveillance in Patients With Colorectal Cancer Who Have Undergone Curative Resection: A Prospective, Multicenter, Randomized, Controlled Trial

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To compare the efficacy of simple versus intensive postoperative surveillance strategies on overall survival and recurrence resectability in patients with resected colorectal cancer.
Prospective, multicenter, randomized controlled trial enrolling 259 patients with stage II or III colorectal cancer after curative resection, followed for a median of 48 months.
Patients were randomized to simple surveillance (N=132; clinical evaluation and serum carcinoembryonic antigen) or intensive surveillance (N=127; simple surveillance plus abdominal CT/ultrasonography, chest radiography, and colonoscopy).
Across the overall cohort, overall survival was not significantly improved with intensive versus simple surveillance (HR = 0.87; 95% CI, 0.49 to 1.54; P = .62).
Intensive surveillance significantly improved overall survival in stage II tumors (HR = 0.34; 95% CI, 0.12 to 0.98; P = .045) and rectal lesions (HR = 0.09; 95% CI, 0.01 to 0.81; P = .03) by increasing recurrence resectability.
Colonoscopy identified the highest proportion (44%) of resectable tumor recurrences in the intensive surveillance group.

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Implication

Randomized trial finds intensive postoperative surveillance improves survival in stage II and rectal colorectal cancer, suggesting clear benefits of routine imaging and colonoscopy.

Cite This Study

Rodríguez‐Moranta et al. (2005) studied this question.

synapsesocial.com/papers/6a94d464222f50f5880b199e https://doi.org/10.1200/jco.2005.02.0826

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Implication

Randomized trial finds intensive postoperative surveillance improves survival in stage II and rectal colorectal cancer, suggesting clear benefits of routine imaging and colonoscopy.

Postoperative Surveillance in Patients With Colorectal Cancer Who Have Undergone Curative Resection: A Prospective, Multicenter, Randomized, Controlled Trial

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Discussion

Implication

Cite This Study

Postoperative Surveillance in Patients With Colorectal Cancer Who Have Undergone Curative Resection: A Prospective, Multicenter, Randomized, Controlled Trial

Key Points

Discussion

Implication

Cite This Study

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