Why the study?
Do extra-platelet sources contribute to the plasma level of thrombospondin in thrombocytopenic patients?
Population
Profoundly thrombocytopenic patients with marrow hypoplasia and patients recovering from bone marrow…
Comparison
Measurement of plasma thrombospondin levels vs Measurement of beta-thromboglobulin levels
Design
Cohort
Authors
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Plasma thrombospondin levels should not yet be interpreted as platelet-derived in thrombocytopenia; hypothesis-generating for non-platelet sources.
Do extra-platelet sources contribute to the plasma level of thrombospondin in thrombocytopenic patients?
Plasma thrombospondin levels do not simply reflect platelet release, as there is a significant background concentration from non-platelet sources.
Dawes et al. (1988) studied this question.
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