Key result
Among critically ill patients with COVID-19, early right ventricular dysfunction was associated with clinical outcome, as nonsurvivors had significantly worse day 1 right ventricle strain compared to survivors (16.3% vs 21.2%, p=0.04).
Why the study?
Cardiac function in critically ill COVID-19 patients had generally been reported only from clinically obtained data, leaving the prevalence and implications of ventricular dysfunction detected by deformation imaging unclear.
Does early ventricular dysfunction identified by echocardiographic deformation imaging predict inpatient survival in critically ill patients with COVID-19?
Cohort (n=110)
Yes
Does early ventricular dysfunction identified by echocardiographic deformation imaging predict inpatient survival in critically ill patients with COVID-19?
Absolute Event Rate: 16.3% vs 21.2%
p-value: p=0.04
In critically ill COVID-19 patients, ventricular dysfunction is common and early right ventricular dysfunction identified by deformation imaging may predict inpatient survival.
May identify occult ventricular dysfunction missed by standard echo in critical COVID-19; leaves open whether routine strain imaging improves risk stratification or outcomes.
Background: Cardiac function of critically ill patients with COVID-19 generally has been reported from clinically obtained data. Echocardiographic deformation imaging can identify ventricular dysfunction missed by traditional echocardiographic assessment. Research Question: What is the prevalence of ventricular dysfunction and what are its implications for the natural history of critical COVID-19? Study Design and Methods: This is a multicenter prospective cohort of critically ill patients with COVID-19. We performed serial echocardiography and lower extremity vascular ultrasound on hospitalization days 1, 3, and 8. We defined left ventricular (LV) dysfunction as the absolute value of longitudinal strain of < 17% or left ventricle ejection fraction (LVEF) of < 50%. Primary clinical outcome was inpatient survival. Interpretation: Among patients with critical COVID-19, LV and RV dysfunction is common, frequently identified only through deformation imaging, and early (day 1) RV dysfunction may be associated with clinical outcome.
No takes yet. Share an insight, caveat, or question.
Lanspa et al. (2023) conducted a cohort in Critically ill with COVID-19 (n=110). Ventricular dysfunction (assessed via deformation imaging) vs. Normal ventricular function was evaluated on Day 1 right ventricle (RV) strain in nonsurvivors vs survivors (p=0.04). Among critically ill patients with COVID-19, early right ventricular dysfunction was associated with clinical outcome, as nonsurvivors had significantly worse day 1 right ventricle strain compared to survivors (16.3% vs 21.2%, p=0.04).
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: