Key result
Cancer patients exhibited a significantly diminished circulating TSP-1/VEGF balance and lower TSP-1 content per platelet (53.6 vs. 94 ng/mL, p<0.05) compared to healthy subjects.
Population
25 cancer patients and 18 healthy subjects
Design
Case-control
Authors
Loading...
Diminished TSP-1/VEGF balance may signal pro-angiogenic state in cancer; hypothesis-generating and requires prospective validation before clinical consideration.
Case-Control (n=43)
p-value: p=<0.05
The circulating TSP-1/VEGF balance is diminished in cancer patients, which may be driven by platelet activation and lead to increased angiogenic activity.
González et al. (2004) conducted a case-control in Cancer (n=43). Cancer vs. Healthy subjects was evaluated on Balance between TSP-1 and VEGF concentrations in serum and serum minus plasma (p=<0.05). Cancer patients exhibited a significantly diminished circulating TSP-1/VEGF balance and lower TSP-1 content per platelet (53.6 vs. 94 ng/mL, p<0.05) compared to healthy subjects.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: