Key result
Salidroside significantly increased cell survival and prevented H2O2-mediated apoptosis in human erythrocytes through antioxidative activity and inhibition of caspase-3 activation.
Why the study?
Does salidroside protect human erythrocytes against hydrogen peroxide-induced apoptosis?
Population
Human erythrocytes exposed to hydrogen peroxide (H2O2)-induced oxidative stress
Comparison
Salidroside [2-ethyl β-D-glucopyranoside] vs Control (H2O2 exposure without salidroside)
Design
Preclinical
Authors
Loading...
Hypothesis-generating for salidroside in oxidative erythrocyte injury; clinical relevance remains untested and should not alter practice.
Does salidroside protect human erythrocytes against hydrogen peroxide-induced apoptosis?
Salidroside protects human erythrocytes from oxidative stress-induced apoptosis via antioxidative mechanisms, caspase-3 inhibition, and prevention of calcium influx.
Qian et al. (2012) studied Oxidative stress-induced apoptosis in human erythrocytes. Salidroside was evaluated on Cell survival and prevention of eryptosis/erythroptosis mediated by H2O2. Salidroside significantly increased cell survival and prevented H2O2-mediated apoptosis in human erythrocytes through antioxidative activity and inhibition of caspase-3 activation.
Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context: