Key result
An 8-month cardiac rehabilitation exercise program did not significantly change serum levels of pro- and anti-inflammatory cytokines in patients with severe Chagas cardiomyopathy.
Why the study?
Cardiac rehabilitation has anti-inflammatory effects in several cardiovascular diseases, but these effects have not been described in Chagas cardiomyopathy, a condition associated with pro-inflammatory imbalance.
Does a cardiac rehabilitation program alter inflammatory cytokine levels in patients with severe Chagas cardiomyopathy?
Does a cardiac rehabilitation program alter inflammatory cytokine levels in patients with severe Chagas cardiomyopathy?
An 8-month cardiac rehabilitation program in patients with severe Chagas cardiomyopathy did not significantly alter serum inflammatory cytokine levels, suggesting it may curb the expected progression of the pro-inflammatory state.
No cytokine change observed with cardiac rehab in severe Chagas cardiomyopathy; hypothesis-generating and requires randomized confirmation before practice implications.
BACKGROUND: Cardiac rehabilitation exerts anti-inflammatory effect on several cardiovascular diseases; however, these effects were not described for Chagas cardiomyopathy, which is associated with pro-inflammatory imbalance. MATERIALS AND METHODS: Ten patients with severe Chagas cardiomyopathy performed 8 months of exercise training in a cardiac rehabilitation program. Interleukin-1 beta (IL-1β), IL-8, IL-10, interferon gamma (IF-γ), tumor necrosis factor alpha (TNF-α), and monocyte chemoattractant protein-1 (MCP-1) serum levels were measured using enzyme-linked immunosorbent assay at baseline, 4, and 8 months. The influence of exercise on cytokine levels was evaluated using the one-way analysis of variance for repeated measurements, with Bonferroni posttest for multiple comparisons. RESULTS: Levels of pro-inflammatory (TNF-α, IL-1β, IL-8, IF-γ, and (MCP-1) and anti-inflammatory (IL-10) cytokines did not vary significantly during the observation period. CONCLUSION: Exercise may benefit patients with severe Chagas cardiomyopathy by curbing the production of pro-inflammatory cytokines in this disease characterized by a continuous state of inflammation.
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Mediano et al. (2020) studied Severe Chagas cardiomyopathy (n=10). Cardiac rehabilitation exercise program vs. Baseline (single-arm) was evaluated on Serum levels of cytokines (IL-1β, IL-8, IL-10, IF-γ, TNF-α, MCP-1) (p=>0.05). An 8-month cardiac rehabilitation exercise program did not significantly change serum levels of pro- and anti-inflammatory cytokines in patients with severe Chagas cardiomyopathy.
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