April 24, 2012PLoS neglected tropical diseasesOpen Access

Deficient Regulatory T Cell Activity and Low Frequency of IL-17-Producing T Cells Correlate with the Extent of Cardiomyopathy in Human Chagas' Disease

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Population

39 subjects from Brazil. Chagas patients included 21 untreated and 8 treated with benznidazole.

Design

Cross-sectional

Authors

PGPaulo Marcos da Matta GuedesUniversidade Federal do Rio Grande do Norte FGFredy R. S. GutierrezUniversidade de Ribeirão Preto GSGrace Kelly SilvaUniversidade de São Paulo

Discussion

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Implication

Immune correlates of LVEF in chronic Chagas cardiomyopathy need prospective confirmation; hypothesis-generating and should not yet change practice.

Structured PICO

Population

39 subjects (29 with Chagas' disease, 10 healthy controls) from Brazil. Chagas patients included 21 untreated (10 free/mild cardiomyopathy, 11 moderate/severe cardiomyopathy) and 8 treated with benznidazole (free/mild cardiomyopathy).

Outcome

Cytokine profile (IL-17, IL-10, TNF-α, IFN-γ) and regulatory T cell frequency/suppressive activity in peripheral blood mononuclear cells (PBMC) cultured with T. cruzi antigensurrogate

In human Chagas' disease, reduced IL-10 and IL-17 production along with deficient regulatory T cell suppressive activity correlates with the severity of cardiomyopathy.

Cite This Study

Guedes et al. (2012) studied this question.

synapsesocial.com/papers/6a89b621b4e829b19bd45c45 https://doi.org/10.1371/journal.pntd.0001630

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Implication

Immune correlates of LVEF in chronic Chagas cardiomyopathy need prospective confirmation; hypothesis-generating and should not yet change practice.

Deficient Regulatory T Cell Activity and Low Frequency of IL-17-Producing T Cells Correlate with the Extent of Cardiomyopathy in Human Chagas' Disease

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Deficient Regulatory T Cell Activity and Low Frequency of IL-17-Producing T Cells Correlate with the Extent of Cardiomyopathy in Human Chagas' Disease

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider