Key result
Heart-infiltrating T cells in human Chagas' cardiomyopathy show significant production of IFN-gamma and TNF-alpha, potentially linked to T. cruzi-induced IL-12 production.
Population
Human and experimental models of T. cruzi infection and Chagas' disease cardiomyopathy
Design
Review
Authors
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Does not support immunomodulation in Chagas cardiomyopathy; leaves open IL-12-driven T-cell mechanisms for targeted trials.
Heart-infiltrating T cells in Chagas' cardiomyopathy produce significant amounts of IFN-gamma and TNF-alpha, potentially linked to IL-12 production and autoimmunity.
Cunha‐Neto et al. (1998) conducted a review in Chagas' disease cardiomyopathy. Heart-infiltrating T cells in human Chagas' cardiomyopathy show significant production of IFN-gamma and TNF-alpha, potentially linked to T. cruzi-induced IL-12 production.
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