What question did this study set out to answer?

To identify immunological differences and epitope recognition profiles that distinguish chronic Chagas disease cardiomyopathy from asymptomatic infection.

January 1, 2001Autoimmunity

Heart-infiltrating and Peripheral T Cells in the Pathogenesis of Human Chagas' Disease Cardiomyopathy

View Full Paper

Ask AI

Bookmark

Population

Patients with chronic Chagas' disease cardiomyopathy and asymptomatic patients chronically infected by…

Design

Review

Authors

ECEdécio Cunha‐NetoHeart Failure / Cardiomyopathy JKJorge KalilNational Council for Scientific and Technological Development

Discussion

Member takes

Implication

Distinct B13/myosin epitope recognition and IFN-γ intensity in CCC may reflect pathogenic autoimmunity; hypothesis-generating for immunomodulatory strategies in Chagas cardiomyopathy.

Key Points

To identify immunological differences and epitope recognition profiles that distinguish chronic Chagas disease cardiomyopathy from asymptomatic infection.
Compared peripheral blood mononuclear cells and heart-infiltrating T cells from patients with chronic Chagas cardiomyopathy against asymptomatic individuals chronically infected with Trypanosoma cruzi.
Assessed T-cell cross-reactivity against cardiac myosin heavy chain and the tandemly repetitive T. cruzi antigen B13.
Profiled qualitative and quantitative production of the inflammatory cytokine interferon-gamma.
Peripheral blood mononuclear cells from cardiomyopathy patients recognized distinct epitopes of cardiac myosin and B13 compared to asymptomatic patients.
Patients with cardiomyopathy mounted qualitatively and quantitatively higher interferon-gamma responses relative to asymptomatic individuals.
Findings linked progressive cardiac tissue damage to inflammatory T1-type cytokines and a delayed-type hypersensitivity reaction sustained by cross-reactive T cells.

Structured PICO

Population

Patients with chronic Chagas' disease cardiomyopathy (CCC) and asymptomatic (ASY) patients chronically infected by Trypanosoma cruzi

Comparator

Asymptomatic (ASY) patients with chronic T. cruzi infection

Outcome

Immunological phenotypes, including T cell recognition of B13 and cardiac myosin epitopes, and IFN-gamma responsesurrogate

Heart damage in Chagas' disease cardiomyopathy may be driven by a delayed-type hypersensitivity process and inflammatory cytokines maintained by heart-crossreactive T cells.

Cite This Study

Cunha‐Neto et al. (2001) studied this question.

synapsesocial.com/papers/6a92890bfa60aefc093ab250 https://doi.org/10.3109/08916930109007383

View Full Paper

Ask AI

Bookmark

Implication

Distinct B13/myosin epitope recognition and IFN-γ intensity in CCC may reflect pathogenic autoimmunity; hypothesis-generating for immunomodulatory strategies in Chagas cardiomyopathy.

Heart-infiltrating and Peripheral T Cells in the Pathogenesis of Human Chagas' Disease Cardiomyopathy

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Heart-infiltrating and Peripheral T Cells in the Pathogenesis of Human Chagas' Disease Cardiomyopathy

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Also Consider

Also Consider