Key result
Both an autoimmune response and a parasite-driven immune response involving inflammatory cytokines and chemokines may play a role in generating the heart lesions leading to Chagas disease cardiomyopathy.
Population
Individuals with Chagas disease cardiomyopathy (CCC) and murine models of the disease
Design
Review
Authors
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Dual immune mechanisms may drive Chagas cardiomyopathy; leaves open targeted therapies pending prospective trials.
This review highlights that both autoimmune and parasite-driven immune responses contribute to the pathogenesis of Chagas disease cardiomyopathy.
Bilate et al. (2008) conducted a review in Chagas disease cardiomyopathy. Both an autoimmune response and a parasite-driven immune response involving inflammatory cytokines and chemokines may play a role in generating the heart lesions leading to Chagas disease cardiomyopathy.
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