Key result
Both an autoimmune response and a parasite-driven immune response involving inflammatory cytokines and chemokines play a role in generating the heart lesions leading to Chagas disease cardiomyopathy.
This review highlights the dual role of autoimmune and parasite-driven immune responses in the pathogenesis of Chagas disease cardiomyopathy.
Does not yet change Chagas cardiomyopathy management; leaves open optimal immune targets for future trials.
Chagas disease continues to be a significant public health problem, as ca. 10 million people are still infected with T. cruzi in Latin America. Decades after primary infection, 30% of individuals can develop a form of chronic inflammatory cardiomyopathy known as Chagas disease cardiomyopathy (CCC). Data from both murine models and human studies support the view that an autoimmune response as well as a parasite-driven immune response involving inflammatory cytokines and chemokines may both play a role in generating the heart lesions leading to CCC. This review aims to summarize recent advances in the understanding of the immunopathogenesis of Chagas disease cardiomyopathy.
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Bilate et al. (2008) conducted a review in Chagas disease cardiomyopathy. Both an autoimmune response and a parasite-driven immune response involving inflammatory cytokines and chemokines play a role in generating the heart lesions leading to Chagas disease cardiomyopathy.
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