Population
Mice chronically infected with Trypanosoma cruzi
Comparison
In vitro exposure to actin, myosin, or T. cruzi… vs Naive mice; unrelated antigen
Design
Preclinical
Authors
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May implicate failed suppression of myosin-reactive T cells in experimental Chagas' autoimmunity; leaves open human relevance and therapeutic targets.
The failure to trigger suppressive mechanisms against autoreactive T cells may be the primary immune defect leading to autoimmunity in experimental Chagas' disease.
Rizzo et al. (1989) studied this question.
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