June 1, 1985Circulation

Autoimmune myocarditis induced by Trypanosoma cruzi.

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Why the study?

Does Trypanosoma cruzi infection induce autoimmune myocarditis in BALB/c mice?

Population

BALB/c mice

Comparison

Infection with a low inoculum of Trypanosoma cruzi vs Matched controls and mice at earlier time points

Design

Preclinical

Follow-up

150 days

Authors

AAAlberto M. AcostaCornell University CSCharles A. Santos-BuchCornell University

Discussion

Member takes

Implication

Supports autoimmune mechanism in Chagas cardiomyopathy; hypothesis-generating in mice and requires human validation before any clinical relevance.

Structured PICO

Does Trypanosoma cruzi infection induce autoimmune myocarditis in BALB/c mice?

Population

BALB/c mice

Intervention

Infection with a low inoculum of Trypanosoma cruzi

Comparator

Matched controls (uninfected) and mice at earlier time points (15, 45, 90, or 120 days post-infection)

Outcome

Splenic lymphocyte cytotoxicity against normal syngeneic neonatal cardiac myofibers in vitro and histologic evidence of myocarditissurrogate

Trypanosoma cruzi infection in mice induces delayed autoimmune myocarditis mediated by cross-reacting antigens, providing a mechanistic explanation for the cardiac lesions seen in Chagas' disease.

Cite This Study

Acosta et al. (1985) studied this question.

synapsesocial.com/papers/6a88357d054eefc4d776fadf https://doi.org/10.1161/01.cir.71.6.1255

Topics

Myocarditis

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Implication

Supports autoimmune mechanism in Chagas cardiomyopathy; hypothesis-generating in mice and requires human validation before any clinical relevance.

Autoimmune myocarditis induced by Trypanosoma cruzi.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Topics

Autoimmune myocarditis induced by Trypanosoma cruzi.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Topics

Also Consider