February 20, 2003Infection and ImmunityOpen Access

Evidence that Development of Severe Cardiomyopathy in Human Chagas' Disease Is Due to a Th1-Specific Immune Response

View Full Paper

Ask AI

Bookmark

Population

Patients with human Chagas' disease, categorized into those presenting with cardiac disease of different…

Design

Cross-sectional

Authors

JGJuliana de Assis Silva GomesUniversidade Federal de Minas Gerais LBLilian M. G. Bahia‐OliveiraUniversidade Federal do Rio de Janeiro MRManoel Otávio da Costa RochaUniversidade Federal de Minas Gerais

Discussion

Member takes

Implication

Immune phenotyping may aid Chagas risk stratification; leaves open whether targeting IFN-gamma or IL-10 alters cardiomyopathy progression.

Structured PICO

Population

Patients with human Chagas' disease, categorized into those presenting with cardiac disease (CARD) of different degrees and those with the indeterminate form of disease (IND).

Outcome

Levels of interleukin 10 (IL-10) and gamma interferon (IFN-gamma) secretion in the supernatant of peripheral blood mononuclear cell (PBMC) cultures, and identification of their cellular sources.surrogate

Severe cardiomyopathy in human Chagas' disease is associated with a strong Th1-specific immune response driven by IFN-gamma production from T lymphocytes, whereas IL-10 from monocytes may regulate the immune response in indeterminate patients.

Cite This Study

Gomes et al. (2003) studied this question.

synapsesocial.com/papers/6a92890bfa60aefc093ab24e https://doi.org/10.1128/iai.71.3.1185-1193.2003

View Full Paper

Ask AI

Bookmark

Implication

Immune phenotyping may aid Chagas risk stratification; leaves open whether targeting IFN-gamma or IL-10 alters cardiomyopathy progression.

Evidence that Development of Severe Cardiomyopathy in Human Chagas' Disease Is Due to a Th1-Specific Immune Response

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Evidence that Development of Severe Cardiomyopathy in Human Chagas' Disease Is Due to a Th1-Specific Immune Response

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider