Key result
Higher IFN-gamma production by PBMC was associated with cure in acutely treated Chagas' disease patients, but with cardiac pathology in chronically infected untreated patients.
Why the study?
Does IFN-gamma production differ between cured/non-cured and cardiac/asymptomatic patients with Chagas' disease?
Population
Chagasic patients, comprising two groups: 1) patients treated with benznidazole during the acute phase of…
Comparison
In vitro stimulation of peripheral blood… vs Within treated group: cured vs non-cured…
Design
Cross-sectional
Authors
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Supports paradoxical IFN-gamma effects by Chagas phase; hypothesis-generating and should not yet change practice.
Observational
Does IFN-gamma production differ between cured/non-cured and cardiac/asymptomatic patients with Chagas' disease?
IFN-gamma may have a paradoxical role in Chagas' disease, potentially favoring cure during the acute phase but influencing the development of cardiac disease during the chronic phase.
Bahia‐Oliveira et al. (1998) conducted an observational in Chagas' disease. IFN-gamma production was evaluated on IFN-gamma levels produced by PBMC. Higher IFN-gamma production by PBMC was associated with cure in acutely treated Chagas' disease patients, but with cardiac pathology in chronically infected untreated patients.
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