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In rabbit platelets, serotonin has been qualitatively localized in the granule fraction in a bound form. The platelet membranes do not appear to contain bound serotonin. The existence of free (soluble) serotonin is likely, although at least part of the dissolved serotonin may have resulted from mechanical disruption of platelet granules.
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Wurzel et al. (1965) studied this question.
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