Haemoglobin H Disease in an English Family

Blood Examination.-Serumprotein normal; blood urea 30 mg./100 ml.; E.S.R. 1 mm. in one hour (Wintrobe) ; serum bilirubin 2.1 mg./100 ml.; serum iron 290 mg./100 ml.; Schumm's test positive ; white cells 3,500/c.mm. (differential count normal) red-cell count 4,600,000/c.mm.; haemoglobin 9.9 g./100 ml.; P.C.V. 37% ; M.C.V. 81 cubic microns; M.C.H.C. 27%; M.C.H. 22 4'g.; reticulocytes 1-6%.The stained smear showed marked anisopoikilocytosis with target cells, burr forms, and microcytes.The osmotic fragility was reduced (Fig. 1).The