Key result
Rheumatoid arthritis was associated with an almost two-fold higher incidence of heart failure compared with a matched control population (OR 1.78; 95% CI 1.22-2.60; P<0.003).
Why the study?
Heart failure appears to be one of the most important contributors to excess mortality in rheumatoid arthritis, prompting assessment of heart failure incidence compared with matched non-rheumatoid arthritis subjects.
Does rheumatoid arthritis increase the incidence of heart failure compared to matched non-RA controls?
Meta-Analysis (n=5,220,883)
Does rheumatoid arthritis increase the incidence of heart failure compared to matched non-RA controls?
Odds Ratio: 1.78 (95% CI 1.22–2.6)
p-value: p=< 0.003
Rheumatoid arthritis is associated with a nearly two-fold increased risk of developing heart failure, with women at particularly high risk, highlighting the need for HF screening in this population.
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RA patients may merit closer HF surveillance; confirms observational link but leaves causal trials open.
Khalid et al. (2020) conducted a meta-analysis in Rheumatoid arthritis (n=5,220,883). Rheumatoid arthritis vs. Age-matched and sex-matched non-RA subjects was evaluated on Incidence of heart failure (OR 1.78, 95% CI 1.22-2.60, p=< 0.003). Rheumatoid arthritis was associated with an almost two-fold higher incidence of heart failure compared with a matched control population (OR 1.78; 95% CI 1.22-2.60; P<0.003).
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