Mediating effect of cumulative lipid profile burden on the effect of diet and obesity on hypertension incidence: a cohort study of people aged 35-65 in rural China

Cumulative lipid profile burden is designed to dynamically measure lipid accumulation, and its effect on hypertension has been poorly studied. Our main purpose was to investigate the effect of cumulative lipid profile burden on the incidence of essential hypertension (EH) and. Secondly, to investigate whether there is a mediating role of cumulative lipid burden in the pathogenesis of the effects of diet and obesity on EH. A total of 1 295 participants were included in the study, which began in 2017. The average follow-up time was 2.98 years. A total of 240 EH patients occurred during the follow-up period. Compared with respective reference groups, the HR (95% CI) of the highest quartile in cumulative TC, TG and HDL burden were 1.747 (1.145 - 2.664), 1.502 (1.038 - 2.173), 0.615 (0.413 - 0.917) for incidence of EH. Participants with EH consumed more red meat and refined grains, and red meat was positively associated with cumulative TC burden . BMI and Waist-To-Height Ratio (WHtR) increased the incidence of EH, and obesity was positively correlated with cumulative TC burden. cumulative TC burden play a partially mediating role in the influence of obesity on EH (βindirect=0.0085, 95%CI: 0.0035, 0.1520). The cumulation TG, TC burden increased the risk of EH, while the cumulation HDL reduced the risk of EH. cumulative TG burden play a partially mediating role in the influence of obesity on EH. Diet was not found to influence hypertension through cumulative lipid profile burden.