Molecular Approaches to Mammalian Genetics

In the last few years a number of new genetic and molecular techniques have emerged for analyzing the mammalian, and especially the human, genome. The genetic analysis has concentrated on the new possibilities of using DNA probes as genetic markers, allowing major progress on both establishing a human linkage map (Botstein et al. 1980) and identifying and using closely linked DNA markers in the genetic analysis of genes defined by mammalian (human and mouse) mutations.