Key result
Obese children demonstrated a significantly thicker mean carotid intima media compared to nonobese controls (0.34 mm vs 0.31 mm).
Why the study?
Is common carotid artery intima media thickness increased in obese children compared to nonobese children?
Case-Control (n=73)
Is common carotid artery intima media thickness increased in obese children compared to nonobese children?
Absolute Event Rate: 0.34% vs 0.31%
Obese children exhibit early signs of subclinical atherosclerosis, as evidenced by significantly increased carotid intima media thickness compared to normal-weight peers.
May indicate early vascular changes in obese children; hypothesis-generating and should not yet change practice or screening.
Purpose : The of common carotid artery intima media thickness (IMT) is an acknowledged noninvasive marker for early atherosclerotic changes. We investigate whether common carotid IMT is different between obese and normal-weight children and also evaluate the relationships IMT with cardiovascular risk factors. Methods : We collected the clinical data (age, sex, pubertal stage, body mass index) and measured blood pressure, glucose, insulin, lipid profiles and adiponectin in 49 obese children (mean age, 12 years) and 24 nonobese children as controls. The control group was composed of 24 nonobese children of the same age, sex and pubertal stage. We measured the carotid IMT of all subjects by B-mode ultrasound with a 7.5-MHz linear transducer and analyzed. Results : Obese children demonstrated a significantly thicker intima media (mean, 0.34 mm, peak, 0.42 mm) compared to the control group (mean, 0.31 mm, peak, 0.38 mm, P
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Lee et al. (2007) conducted a case-control in Obesity (n=73). Obesity vs. Nonobese children was evaluated on Mean carotid intima media thickness. Obese children demonstrated a significantly thicker mean carotid intima media compared to nonobese controls (0.34 mm vs 0.31 mm).
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