The study identifies the troponin binding site on tropomyosin at approximately 14 nm from the carboxyl terminus, contributing to the structural understanding of muscle contraction.
Should not change cardiac troponin diagnostics or therapies; extends thin-filament models but leaves open human translation.
Selective staining with methyl mercury is employed to locate the position of the thiol groups in magnesium paracrystals of α-tropomyosin. This information establishes the absolute orientation of the tropomyosin molecules in the paracrystal and so locates the troponin binding site approximately 14 nm from the carboxyl terminus of the molecule.
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Murray Stewart (1975) studied this question.
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