Key result
The receptor-binding site of the measles virus hemagglutinin protein forms a conserved neutralizing epitope, meaning viral escape from neutralization requires loss of receptor-binding activity.
May guide conserved-epitope measles vaccines; leaves open clinical translation of escape constraints.
Here, we provide direct evidence that the receptor-binding site of measles virus (MV) hemagglutinin protein itself forms an effective conserved neutralizing epitope (CNE). Several receptor-interacting residues constitute the CNE. Thus, viral escape from neutralization has to be associated with loss of receptor-binding activity. Since interactions with both the signaling lymphocyte activation molecule (SLAM) and nectin4 are critical for MV pathogenesis, its escape, which results from loss of receptor-binding activity, should not occur in nature.
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Tahara et al. (2013) studied Measles virus. Receptor-binding site of measles virus hemagglutinin protein was evaluated. The receptor-binding site of the measles virus hemagglutinin protein forms a conserved neutralizing epitope, meaning viral escape from neutralization requires loss of receptor-binding activity.
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