Key result
A recombinant measles virus with a wild-type H protein entered cells through the SLAM receptor two to three times more efficiently than through CD46, whereas the attenuated Edmonston strain preferred CD46.
Population
Recombinant measles virus strains, CD46-expressing Vero cells, and peripheral blood mononuclear cells
Comparison
Recombinant measles virus with wild-type H… vs Recombinant measles virus with H protein of the…
Design
Preclinical
Authors
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May inform measles attenuation strategies in models; leaves open human receptor studies before clinical translation.
Wild-type measles virus H protein and the asparagine 481 mutation enhance cell entry efficiency through specific receptors, influencing viral pathogenicity.
Schneider et al. (2002) studied Measles virus infection. Recombinant measles viruses with different H proteins vs. Attenuated MV-Edm strain was evaluated on Cell entry efficiency and syncytium formation. A recombinant measles virus with a wild-type H protein entered cells through the SLAM receptor two to three times more efficiently than through CD46, whereas the attenuated Edmonston strain preferred CD46.
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