Population
Chinese hamster ovary (CHO) cells expressing BC-CYT2, B-CYT2 and BC-CYT1 CD46 isoforms
Comparison
Measles virus (MV) infection vs Parental CHO cells not expressing CD46 isoforms
Design
Preclinical
Authors
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Does not support changes to measles virus receptor targeting; leaves open STP and tail domain roles in vivo.
Specific extracellular STP regions and cytoplasmic tails of CD46 are not essential for measles virus binding, infection, and receptor down-regulation in vitro.
Gerlier et al. (1994) studied this question.
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