Key result
A systematic review of 5 studies found scant evidence supporting the commonly used 120 mIU/mL measles threshold of protection, with symptomatic individuals identified despite exceeding this titer.
Why the study?
Many studies assume the serologic correlate of protection from measles is 120 mIU/mL, but the evidence supporting this threshold had not been systematically examined.
Does a preexposure antibody concentration of 120 mIU/mL correlate with protection from measles disease?
Population
5 included studies reporting a measles correlate of protection
Design
Systematic review
Authors
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Questions validity of 120 mIU/mL measles protection threshold; challenges assumptions and highlights need for validated correlates.
Systematic Review (n=5)
Does a preexposure antibody concentration of 120 mIU/mL correlate with protection from measles disease?
The commonly used 120 mIU/mL threshold for measles immunity is based on scant data, as symptomatic cases have been identified above this level.
Bolotin et al. (2019) conducted a systematic review in Measles (n=5). Serologic correlate of protection (120 mIU/mL) was evaluated on Measles correlate of protection. A systematic review of 5 studies found scant evidence supporting the commonly used 120 mIU/mL measles threshold of protection, with symptomatic individuals identified despite exceeding this titer.
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