Key result
Evaluation of measles virus strains in Hokkaido, Japan (2006-2015) identified several novel amino acid changes in functional regions of their hemagglutinin proteins.
Observational
Measles virus strains in Hokkaido, Japan (2006-2015) exhibited novel amino acid changes in functional regions of the hemagglutinin protein, highlighting the need for ongoing molecular surveillance.
Answers are grounded in this paper and cite their sources.
May warrant enhanced measles surveillance; leaves open functional and vaccine implications of these changes.
Strains of measles virus of genotypes D5, H1, D4, D8, and B3 were detected among epidemic, endemic, imported and import-associated cases in Hokkaido district, Japan, during 2006-2015. In the present study, their antigenic features were evaluated by determining the complete nucleotide sequences of their hemagglutinin proteins, which are a major target for neutralizing antibodies, and their amino acid sequences deduced. It was found that the hemagglutinin proteins of these strains had several novel amino acid changes in some functional regions. Although these strains have not caused further infections thus far, these antigenic changes should continue to be monitored to maintain their elimination status.
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Miyoshi et al. (2018) conducted an observational in Measles. Measles virus strains (genotypes D5, H1, D4, D8, and B3) was evaluated on Amino acid changes in hemagglutinin proteins. Evaluation of measles virus strains in Hokkaido, Japan (2006-2015) identified several novel amino acid changes in functional regions of their hemagglutinin proteins.
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