Key result
All 59 wild-type measles virus isolates collected across 16 provinces in China in 2004 belonged to genotype H1, demonstrating ongoing endemic transmission of multiple lineages of a single genotype.
Observational (n=59)
Yes
Genotype H1 was the endemic measles virus circulating in China in 2004, with multiple lineages indicating ongoing endemic transmission.
Provides baseline for measles surveillance in China; leaves open current genotype distribution and transmission dynamics.
Genetic characterization of wild-type measles virus was studied using nucleotide sequencing of the C-terminal region of the N protein gene and phylogenetic analysis on 59 isolates from 16 provinces of China in 2004. The results showed that all of the isolates belonged to genotype H1. 51 isolates were belonged to cluster 1 and 8 isolates were cluster 2 and Viruses from both clusters were distributed throughout China without distinct geographic pattern. The nucleotide sequence and predicted amino acid homologies of the 59 H1 strains were 96.5%-100% and 95.7%-100%, respectively. The report showed that the transmission pattern of genotype H1 viruses in China in 2004 was consistent with ongoing endemic transmission of multiple lineages of a single, endemic genotype. Multiple transmission pathways leaded to multiple lineages within endemic genotype.
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Zhang et al. (2008) conducted an observational in Measles (n=59). Genetic characterization was evaluated on Measles virus genotype. All 59 wild-type measles virus isolates collected across 16 provinces in China in 2004 belonged to genotype H1, demonstrating ongoing endemic transmission of multiple lineages of a single genotype.
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