Key result
Phylogenetic analysis of 6 wild-type measles virus isolates from Nantong, China in 2010 revealed that all clustered within genotype H1, indicating continued endemic transmission.
Observational (n=205)
Measles outbreaks in Nantong, China in 2010 were driven by the endemic H1 genotype, highlighting the need for continued surveillance and vaccination efforts.
Measles control in China is monitored in part by surveillance of circulating wild-type viruses. The objective of this study was genetic characterization and phylogenetic analysis of measles strains in the Nantong City region of Jiangsu province, China, during 2010. Sera from suspected cases were tested for IgM antibodies and measles virus isolated by inoculation of transport medium onto Vero/SLAM cells. Isolated strains were phylogenetically analysed according to the nucleotide sequence of the C-terminal region of the nucleoprotein gene amplified by RT-PCR. The results revealed 34 cases confirmed by positive IgM, for an incidence of 0·45/100 000. Six isolates identified were all clustered within genotype H1. The findings reported here support continued endemic transmission of measles virus in China.
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LI et al. (2011) conducted an observational in Measles (n=205). Wild-type measles virus was evaluated on Measles virus genotype. Phylogenetic analysis of 6 wild-type measles virus isolates from Nantong, China in 2010 revealed that all clustered within genotype H1, indicating continued endemic transmission.
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