Key result
Cytidines at hexamer phases 1 and 6 were most accessible to chemical modification, whereas mRNA editing was most extensive when the stutter-site C was in positions 2 to 5.
Population
Sendai virus nucleocapsids and cell culture infections
Comparison
Displacement of a model editing site 1 nt at a… vs Matched set of viruses with different hexamer…
Design
Preclinical
Authors
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May enable targeted antiviral design; extends viral RNA editing models but leaves open human translation.
The N subunit imprints the nucleotide sequence it is associated with, affecting both the initiation of viral RNA synthesis and mRNA editing, superimposing another code upon the genetic code.
ISENI et al. (2002) studied Sendai virus infection. Displacement of editing site relative to genome ends was evaluated on mRNA editing and chemical modification sensitivity. Cytidines at hexamer phases 1 and 6 were most accessible to chemical modification, whereas mRNA editing was most extensive when the stutter-site C was in positions 2 to 5.
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