Key result
Recombinant Newcastle disease virus generated from cDNA was indistinguishable from the parental wild-type virus in growth characteristics and had an identical intracerebral pathogenicity index of 0.29.
Population
Cells stably expressing T7 RNA polymerase, embryonated specific-pathogen-free chicken eggs, and day-old SPF…
Comparison
Generation of recombinant lentogenic Newcastle… vs Parental wild-type virus (vaccine strain Clone-30)
Design
Preclinical
Authors
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Recombinant NDV rescue from cDNA preserves wild-type traits; extends reverse genetics tools for avian paramyxovirus research but requires further validation.
Absolute Event Rate: 0.29% vs 0.29%
Recombinant lentogenic Newcastle disease virus can be reproducibly generated from cDNA and is phenotypically indistinguishable from the parental wild-type vaccine strain.
Römer-Oberdörfer et al. (1999) studied Newcastle disease virus. Recombinant lentogenic Newcastle disease virus (NDV) from cDNA vs. Parental wild-type virus was evaluated on Intracerebral pathogenicity index. Recombinant Newcastle disease virus generated from cDNA was indistinguishable from the parental wild-type virus in growth characteristics and had an identical intracerebral pathogenicity index of 0.29.
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