Key result
The herpes simplex virus virion host shutoff protein (vhs) modulates gene expression at the translational level and activates cap-independent translation through specific cis-acting elements.
The HSV vhs protein can modulate gene expression at the translational level and activate cap-independent translation through specific cis-acting elements.
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Provides mechanistic insight into HSV translation; leaves open in vivo validation and therapeutic targeting.
Saffran et al. (2010) studied Herpes Simplex Virus infection mechanisms. Herpes Simplex Virus Virion Host Shutoff Protein (vhs) vs. Absence of vhs or mutant vhs was evaluated on Reporter gene expression (beta-galactosidase and CAT) in transient-transfection assays. The herpes simplex virus virion host shutoff protein (vhs) modulates gene expression at the translational level and activates cap-independent translation through specific cis-acting elements.
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