Key result
A mechanosensitive Ca2+-permeable channel mediating flow-induced Ca2+ entry into vascular endothelial cells was identified and found to be inhibited by protein kinase G activation.
Population
Vascular endothelial cells
Comparison
Application of 8-Br-cGMP, active protein kinase… vs Control conditions
Design
Preclinical
Authors
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Does not support clinical translation; leaves open relevance of this channel to human flow-mediated vasodilation.
Identifies a PKG-sensitive mechanosensitive Ca2+ channel as the primary pathway for flow-induced Ca2+ entry in vascular endothelial cells, a key step in flow-induced vasodilation.
Yao et al. (2000) studied this question. Protein kinase G activation was evaluated on Channel activity and Ca2+ entry. A mechanosensitive Ca2+-permeable channel mediating flow-induced Ca2+ entry into vascular endothelial cells was identified and found to be inhibited by protein kinase G activation.
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