What question did this study set out to answer?

To evaluate the progression of oropharyngeal dysphagia and identify risk factors associated with accelerated swallowing impairment and earlier PEG tube placement in amyotrophic lateral sclerosis.

July 23, 2021DysphagiaOpen Access

Progression of Oropharyngeal Dysphagia in Amyotrophic Lateral Sclerosis: A Retrospective Cohort Study

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To evaluate the progression of oropharyngeal dysphagia and identify risk factors associated with accelerated swallowing impairment and earlier PEG tube placement in amyotrophic lateral sclerosis.
Conducted a retrospective cohort study of 108 patients diagnosed with amyotrophic lateral sclerosis.
Performed fiberoptic endoscopic evaluation of swallowing every six months using the Penetration Aspiration Scale until PEG indication or death.
Assessed dysphagia onset and PEG indication risk across bulbar versus non-bulbar onset and progression index categories using person-time incidence rates and Cox regression survival analysis.
Swallowing deterioration risk was significantly higher in patients with bulbar onset (HR = 2.781, P < 0.01) and those with a fast progression index (HR = 2.811, P < 0.01).
Risk for PEG tube indication was significantly elevated in patients with a fast progression index (HR = 2.474, P < 0.01) and bulbar onset (HR = 2.654, P < 0.01).

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Implication

Retrospective cohort study demonstrates bulbar onset and rapid progression accelerate dysphagia in amyotrophic lateral sclerosis, indicating need for timely feeding tube intervention.

Cite This Study

Mariani et al. (2021) studied this question.

synapsesocial.com/papers/6a94de18222f50f5880b1c76 https://doi.org/10.1007/s00455-021-10346-9

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Implication

Retrospective cohort study demonstrates bulbar onset and rapid progression accelerate dysphagia in amyotrophic lateral sclerosis, indicating need for timely feeding tube intervention.

Progression of Oropharyngeal Dysphagia in Amyotrophic Lateral Sclerosis: A Retrospective Cohort Study

Key Points

Discussion

Implication

Cite This Study

Progression of Oropharyngeal Dysphagia in Amyotrophic Lateral Sclerosis: A Retrospective Cohort Study

Key Points

Discussion

Implication

Cite This Study

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