Preclinical evaluation assesses anxiolytic properties of Citrus reticulata peel extracts, suggesting potential therapeutic applications for managing anxiety.
Introduction: Herbal medicines are getting more interest because of their cost-effective, eco-friendly attributes and proper reprieve from disease condition. The present study was designed to evaluate the anxiolytic activity potentials in peels of Citrus reticulata (Family: Rutaceae) in Libya. Methods: The peel of the fruits were separated and subjected to cold extraction using 99% Methanol and hot water extraction. The extracts obtained were screened for anxiolytic activity of extracts at 1.25 to 5 mg/Kg body weight concentrations and were assessed by Elevated Plus Maze. Results: The results revealed that, both extracts treated animals have shown significant anxiolytic activity. From the results it was evident that citrus peel extract of Citrus reticulata exhibited significant anxiolytic activity. Conclusion: From the results it was evident that Citrus reticulata has prominent activity in terms of parameters assessed in a dose dependent manner.
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Abdul M Gbaj (2019) studied this question.
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