Key result
The slope of the linear regression line between PCWP and ANP during the acute phase of myocardial infarction was significantly lower, by about one-third, than at 1 month.
Why the study?
Is the secretion of atrial natriuretic peptide (ANP) insufficient relative to hemodynamics during the acute phase of myocardial infarction compared to the chronic phase?
Observational (n=45)
Is the secretion of atrial natriuretic peptide (ANP) insufficient relative to hemodynamics during the acute phase of myocardial infarction compared to the chronic phase?
The secretion of atrial natriuretic peptide during the acute phase of myocardial infarction appears to be insufficient relative to the elevated filling pressures compared to the chronic phase.
May indicate blunted ANP response to PCWP in acute MI; hypothesis-generating for hemodynamic or therapeutic implications.
To investigate the secretion of the plasma levels of atrial natriuretic peptide (ANP) in patients with acute myocardial infarction (AMI), we evaluated the relationship between plasma levels of ANP and pulmonary capillary wedge pressure (PCWP) in 45 consecutive patients during the acute phase of AMI ( approximately 12 h after the attack) (group 1) and compared data with those obtained after 1 mo (group 2). In both groups 1 and 2, plasma ANP levels significantly correlated with PCWP. The slope of the linear regression line between the PCWP and ANP in group 1 was significantly lower, by about one-third, than that in group 2. In addition, we examined changes in ANP levels and left ventricular end-diastolic pressure (LVEDP) over 180 min after AMI induced by injection of microspheres into the left coronary arteries of three dogs. The LVEDP and ANP levels 30 min after AMI were significantly higher than those before; however, despite the persistent high LVEDP during the 180 min after AMI, ANP levels decreased gradually and significantly to 63% of the peak level at 150 min. These findings suggest that the secretion of ANP during the acute phase of myocardial infarction may be insufficient relative to the chronic phase.
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Maeda et al. (2000) conducted an observational in Acute myocardial infarction (n=45). Acute phase of myocardial infarction vs. Chronic phase (1 month after attack) was evaluated on Relationship between plasma levels of atrial natriuretic peptide (ANP) and pulmonary capillary wedge pressure (PCWP). The slope of the linear regression line between PCWP and ANP during the acute phase of myocardial infarction was significantly lower, by about one-third, than at 1 month.
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