Key result
Participants in the highest quartile of the dietary index for gut microbiota had a significantly lower odds of metabolic syndrome compared to those in the lowest quartile (OR 0.80).
Why the study?
Metabolic syndrome poses a major public health challenge, but the link between the dietary index for gut microbiota and the odds of metabolic syndrome remains elusive.
Is a higher dietary index for gut microbiota associated with reduced odds of metabolic syndrome in adults?
Cross-Sectional (n=20,999)
Is a higher dietary index for gut microbiota associated with reduced odds of metabolic syndrome in adults?
Odds Ratio: 0.8 (95% CI 0.69–0.92)
Absolute Event Rate: 21% vs 25%
p-value: p=0.003
A diet that favorably influences the gut microbiota is associated with lower odds of metabolic syndrome, an effect partially mediated by reduced dietary inflammation.
Supports hypothesis-generating role for gut microbiota diets in metabolic syndrome; leaves open need for prospective studies before clinical adoption.
Background: Metabolic syndrome (MetS) poses a huge global public health challenge. The dietary index for gut microbiota (DI-GM) measures the influence of diets on the microbiome, but its link with the odds of MetS is elusive. This paper examined the link between DI-GM and MetS and investigated the mediating role of the dietary inflammatory index (DII). Methods: Data were sourced from the 2007-2018 NHANES for adults diagnosed with MetS. A total of 20,999 participants were included in the analysis. Dietary data were recorded via two 24-h dietary recalls, from which DI-GM and DII were calculated. Multivariate weighted logistic regression and restricted cubic spline (RCS) analyses were leveraged to assess the link between DI-GM and MetS. Mediation analysis was implemented to determine the role of DII in this association. Subgroup and sensitivity analyses were also implemented. Results: < 0.001]. Subgroup analysis showed consistent negative associations between higher DI-GM (Q4) and MetS across various demographic and lifestyle subgroups, with no statistically significant interactions observed (P interaction > 0.05). Conclusion: High DI-GM levels are linked with a significantly reduced odds of MetS, with DII partially mediating this association.
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Wang et al. (2025) conducted a cross-sectional in Metabolic syndrome (n=20,999). Dietary index for gut microbiota (DI-GM) vs. Lowest DI-GM quartile (Q1) was evaluated on Odds of metabolic syndrome (OR 0.80, 95% CI 0.69-0.92, p=0.003). Participants in the highest quartile of the dietary index for gut microbiota had a significantly lower odds of metabolic syndrome compared to those in the lowest quartile (OR 0.80).
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