January 1, 1984AJP Endocrinology and Metabolism

Dietary carbohydrate induces lipogenesis and very-low-density lipoprotein synthesis

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Why the study?

Does dietary carbohydrate (sucrose) induce lipogenesis and VLDL synthesis in rat hepatocytes?

Population

Hepatocytes obtained from rats

Comparison

Sucrose feeding and glucose challenge vs Hepatocytes from control rats

Design

Preclinical

Authors

JBJ R BoogaertsLouisiana State University MMM Malone-McNealUniversity Medical Center New Orleans JAJ Archambault-SchexnayderUniversity Medical Center New Orleans

Discussion

Member takes

Implication

Sucrose enhances rat hepatocyte VLDL assembly capacity; hypothesis-generating for human dietary carbohydrate effects on lipoprotein metabolism.

Structured PICO

Does dietary carbohydrate (sucrose) induce lipogenesis and VLDL synthesis in rat hepatocytes?

Population

Hepatocytes obtained from rats

Intervention

Sucrose feeding (in vivo) and glucose challenge (in vitro)

Comparator

Hepatocytes from control rats

Outcome

Rate of triacylglycerol secretion and synthesissurrogate

Dietary carbohydrate coinduces lipogenesis and apolipoprotein synthesis in vivo, increasing the capacity of hepatocytes to assemble and secrete triacylglycerol-rich lipoproteins.

Cite This Study

Boogaerts et al. (1984) studied this question.

synapsesocial.com/papers/6a94e146a9fda6dc960f2e46 https://doi.org/10.1152/ajpendo.1984.246.1.e77

View Full Paper

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Implication

Sucrose enhances rat hepatocyte VLDL assembly capacity; hypothesis-generating for human dietary carbohydrate effects on lipoprotein metabolism.

Dietary carbohydrate induces lipogenesis and very-low-density lipoprotein synthesis

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Dietary carbohydrate induces lipogenesis and very-low-density lipoprotein synthesis

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider