December 20, 2016Pacing and Clinical Electrophysiology
The Neutrophil‐to‐Lymphocyte Ratio Predicts All‐Cause Mortality in Patients with Implantable Cardioverter Defibrillators
Key result
A high neutrophil-to-lymphocyte ratio (≥2.1) independently predicted all-cause mortality (29% overall event rate) in patients with cardiomyopathy who received an ICD.
Why the study?
Does a high neutrophil-to-lymphocyte ratio predict all-cause mortality or appropriate ICD shocks in patients with cardiomyopathy receiving an ICD?
Population
120 consecutive patients with cardiomyopathy who received an implantable cardioverter-defibrillator, mean…
Comparison
High neutrophil-to-lymphocyte ratio measured on… vs Low neutrophil-to-lymphocyte ratio (NLR <2.1)
Design
Cohort
Follow-up
median 61.2 months
Authors
Discussion
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Member takes
Implication
High NLR may flag higher mortality risk in ICD recipients; hypothesis-generating and should not yet change practice or predict shocks.
Study Design
Type
Cohort (n=120)
Structured PICO
Does a high neutrophil-to-lymphocyte ratio predict all-cause mortality or appropriate ICD shocks in patients with cardiomyopathy receiving an ICD?
P
Population
120 patients (mean age 64 years) with cardiomyopathy who received an implantable cardioverter-defibrillator, followed for a median of 61.2 months.
E
Exposure
High neutrophil-to-lymphocyte ratio (NLR ≥2.1) measured on the morning of the day of implantation
C
Comparator
Low neutrophil-to-lymphocyte ratio (NLR <2.1)
O
Outcome
All-cause mortality or appropriate ICD shockhard clinical
A high neutrophil-to-lymphocyte ratio (≥2.1) is an independent predictor of all-cause mortality in patients with cardiomyopathy receiving an ICD.
Cite This Study
Hashimoto et al. (2016) conducted a cohort in Cardiomyopathy with implantable cardioverter-defibrillators (n=120). Neutrophil-to-lymphocyte ratio (NLR) was evaluated on All-cause mortality or appropriate ICD shock. A high neutrophil-to-lymphocyte ratio (≥2.1) independently predicted all-cause mortality (29% overall event rate) in patients with cardiomyopathy who received an ICD.