What question did this study set out to answer?

To examine whether astaxanthin can alleviate fipronil-induced neurotoxicity, oxidative stress, neuroinflammation, and apoptotic brain injury in male rats.

April 24, 2025Scientific ReportsOpen Access

Astaxanthin alleviates fipronil-induced neuronal damages in male rats through modulating oxidative stress, apoptosis, and inflammatory markers

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Authors

MHMona HafezAlexandrovska Hospital AEAli H. El‐FarDamanhour University SESamar S. ElblehiAlexandria University

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Implication

Controlled laboratory study demonstrates astaxanthin mitigates fipronil-induced neurotoxicity in rats, highlighting its therapeutic potential against pesticide poisoning.

Key Points

To examine whether astaxanthin can alleviate fipronil-induced neurotoxicity, oxidative stress, neuroinflammation, and apoptotic brain injury in male rats.
Thirty-two adult male Wistar rats were divided into four groups (N=8 per group): Control, astaxanthin alone (20 mg/kg bwt/day), fipronil alone (20 mg/kg bwt/day), and astaxanthin plus fipronil.
Evaluated brain neurotransmitters, oxidative and antioxidant markers, proinflammatory cytokines, histopathology in cerebral and cerebellar tissues, and immunohistochemical expression of caspase-3 and glial fibrillary acidic protein (GFAP).
Fipronil administration markedly increased ACh, dopamine, malondialdehyde, COX-2, and inflammatory cytokines (TNF-α, IL-1β, IL-6), while substantially reducing AChE, GABA, serotonin, and antioxidant defenses (GSH, CAT, T-SOD).
Fipronil induced severe cerebral and cerebellar tissue alterations along with intense positive staining for caspase-3 and GFAP, all of which were partially attenuated by co-administration of astaxanthin.

Cite This Study

Hafez et al. (2025) studied this question.

synapsesocial.com/papers/6a94e8a9d8c98694b3eff507 https://doi.org/10.1038/s41598-025-95447-3

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Implication

Controlled laboratory study demonstrates astaxanthin mitigates fipronil-induced neurotoxicity in rats, highlighting its therapeutic potential against pesticide poisoning.

Astaxanthin alleviates fipronil-induced neuronal damages in male rats through modulating oxidative stress, apoptosis, and inflammatory markers

Discussion

Member takes

Implication

Key Points

Cite This Study

Astaxanthin alleviates fipronil-induced neuronal damages in male rats through modulating oxidative stress, apoptosis, and inflammatory markers

Discussion

Member takes

Implication

Key Points

Cite This Study

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