Key result
Combined catheter ablation and left atrial appendage closure resulted in an annualized stroke rate of 0.9% over 35 months, compared to an expected rate of 3.2% without anticoagulation.
Why the study?
Does combined catheter ablation and left atrial appendage closure reduce stroke and bleeding rates in patients with non-valvular atrial fibrillation?
Observational (n=349)
Yes
Does combined catheter ablation and left atrial appendage closure reduce stroke and bleeding rates in patients with non-valvular atrial fibrillation?
Absolute Event Rate: 0.9% vs 3.2%
Combined catheter ablation and left atrial appendage closure is feasible and associated with a low long-term stroke rate (0.9% annualized) despite a 51% AF recurrence rate.
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Associated with low stroke rates despite AF recurrence; leaves open whether combined ablation-LAA closure reduces events versus anticoagulation.
Wintgens et al. (2018) conducted an observational in Non-valvular atrial fibrillation (n=349). Combined catheter ablation and left atrial appendage closure vs. Expected rate without anticoagulation was evaluated on Annualized stroke rate. Combined catheter ablation and left atrial appendage closure resulted in an annualized stroke rate of 0.9% over 35 months, compared to an expected rate of 3.2% without anticoagulation.
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