Key result
A systemic immune inflammation index cutoff of 672.3 predicted critical carotid artery stenosis (≥70%) with 71.2% sensitivity and 60.1% specificity.
Why the study?
Stroke contributes significantly to morbidity and mortality, leading researchers to investigate whether the systemic immune inflammation index could predict the likelihood of developing carotid artery stenosis.
Does an increased systemic immune-inflammation index predict critical carotid artery stenosis in patients undergoing carotid angiography?
Observational (n=418)
Does an increased systemic immune-inflammation index predict critical carotid artery stenosis in patients undergoing carotid angiography?
p-value: p=<.001
An elevated systemic immune-inflammation index is independently associated with critical carotid artery stenosis and may serve as a predictive biomarker.
Stroke is a significant contributor to morbidity and mortality. The present study investigated how the systemic immune inflammation index (SII) could be used to predict the likelihood of developing carotid artery stenosis (CAS), which can be seen using carotid artery angiography (CAAG). This study comprised 418 individuals who underwent CAAG for CAS. SII was calculated by multiplying the platelet count by the neutrophil/lymphocyte ratio (NLR). The patients were divided into two groups: non-critical and critical CAS (stenosis below %70 and above ≥70%, respectively). Compared with the non-critical CAS, the critical CAS group had greater high sensitivity C-reactive protein levels (4.5 [3.1-5.7] vs 3.9 [2-5] [mg/L], P < .001), NLR (4.1 [2.9-7.5] vs 2.9 [1.8-3.7], P < .001), platelet/lymphocyte ratio (233 [110-297] vs 119 [96-197], P < .001), and SII (860 [608-2455] vs 604 [458-740], P < .001). Receiver Operating Characteristic Curve analysis demonstrated the best cutoff value of 672.3 for SII to predict the critical CAS with 71.2% sensitivity and 60.1% specificity. According to our study, an increase in SII is an independent predictor of the severity of CAS in patients undergoing CAAG.
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Keleşoğlu et al. (2022) conducted an observational in Carotid artery stenosis (n=418). Systemic immune inflammation index (SII) was evaluated on Critical carotid artery stenosis (≥70%) (p=<.001). A systemic immune inflammation index cutoff of 672.3 predicted critical carotid artery stenosis (≥70%) with 71.2% sensitivity and 60.1% specificity.
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