Key result
Consumption of a saturated fat diet during adolescence in mice promoted cardiac steatosis, potentially due to insufficient leptin production from white adipose tissue.
Why the study?
The study was conducted to identify the age-dependent effect of diets containing elevated amounts of either saturated or unsaturated fatty acids on cardiac steatosis.
Does a saturated fatty-acid-enriched diet induce cardiac steatosis in adolescent mice compared to an unsaturated fatty-acid-enriched diet?
Does a saturated fatty-acid-enriched diet induce cardiac steatosis in adolescent mice compared to an unsaturated fatty-acid-enriched diet?
High saturated fat intake during adolescence promotes cardiac steatosis in mice, potentially mediated by insufficient leptin production.
Answers are grounded in this paper and cite their sources.
Saturated fat in adolescence may affect cardiac metabolism in mice; leaves open human relevance and should not change practice.
SCOPE: To identify the age-dependent effect of diets containing elevated amounts of either saturated or unsaturated fatty acids on cardiac steatosis in mice. METHODS AND RESULTS: Five- and eight-week-old C57BL/6J mice cohorts are given free access to either a saturated or an unsaturated fatty-acid-enriched diet during 8 weeks. Body weight (BW) and food intake are monitored during this period. Cardiac lipid content, carnitine palmitoyltransferase-I (CPT-I) activity, and the amount of uncoupling proteins 2 and 3 (UCP2 and UCP3) are analyzed and correlated with blood leptin concentration. Leptin and PPARγ gene expression is quantified in white adipose tissue (WAT). Both diets have a similar effect on food intake, BW, and adiposity, independently of the age. Nevertheless, cardiac steatosis is specifically identified in adolescent mice consuming the saturated diet. These animals also display lower activity of cardiac CPT-I, a down-regulation of cardiac UCP2, together with lower concentration of plasma leptin. Accordingly, leptin gene expression is reduced in the visceral WAT. CONCLUSION: Consumption of diets containing elevated amounts of saturated fat during adolescence and early adult life promotes cardiac steatosis in mice. An insufficient endocrine activity of WAT, in terms of leptin production, may account for such an effect.
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Plaza et al. (2019) studied Cardiac steatosis. Saturated fatty-acid-enriched diet vs. Unsaturated fatty-acid-enriched diet was evaluated on Cardiac steatosis. Consumption of a saturated fat diet during adolescence in mice promoted cardiac steatosis, potentially due to insufficient leptin production from white adipose tissue.
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