Key result
Gymnema sylvestre extract significantly suppressed the increase of body weight, serum lipids, insulin, leptin, and liver inflammation in mice fed a high-fat diet.
Why the study?
Does Gymnema sylvestre extract prevent metabolic disorders in male C57BL/6J mice fed a high-fat diet?
Does Gymnema sylvestre extract prevent metabolic disorders in male C57BL/6J mice fed a high-fat diet?
Gymnema sylvestre extract demonstrates preventative effects against high-fat diet-induced metabolic disorders, including insulin resistance and liver steatosis, in a mouse model.
Answers are grounded in this paper and cite their sources.
Gymnema sylvestre merits further preclinical testing in metabolic models; leaves open translation to human prevention or treatment.
This study used an integrated approach to investigate the effects of Gymnema sylvestre (GS) extract as a functional dietary supplement with a high-fat diet. This approach examined insulin resistance, the dysfunction of adipose tissue, and liver steatosis. Male C57BL/6J mice were fed a normal chow or high-fat diet (HFD) for the acute and chronic study, in addition to GS in different doses (100, 250 and 500[Formula: see text]mg/kg body weight). Their body composition changes, serum lipid and glucose parameters, adipose and liver tissue histology, and gene expression were measured. It was found that GS significantly suppressed the increase of body weight, serum levels of lipid, insulin and leptin, and adipose tissue, and liver inflammation. GS also demonstrated hypoglycemic effects due to the amylase inhibition activity. Our results support the existence of a relationship between the HFD induced insulin resistance, adipose dysfunction and liver steatosis. In conclusion, GS works as a functional dietary supplement with preventative effects against metabolic disorder.
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Kim et al. (2017) studied High-fat diet-induced metabolic disorders. Gymnema sylvestre (GS) extract vs. High-fat diet without GS was evaluated on Body weight, serum levels of lipid, insulin and leptin, adipose tissue, and liver inflammation. Gymnema sylvestre extract significantly suppressed the increase of body weight, serum lipids, insulin, leptin, and liver inflammation in mice fed a high-fat diet.
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