Why the study?
Does Gymnema sylvestre extract prevent metabolic disorders in male C57BL/6J mice fed a high-fat diet?
Population
Male C57BL/6J mice fed a normal chow or high-fat diet (HFD)
Comparison
Gymnema sylvestre extract at doses of 100, 250… vs Normal chow or high-fat diet without Gymnema…
Design
Preclinical
Key result
Gymnema sylvestre extract significantly suppressed the increase of body weight, serum lipids, insulin, leptin, and liver inflammation in mice fed a high-fat diet.
Authors
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Gymnema sylvestre merits further preclinical testing in metabolic models; leaves open translation to human prevention or treatment.
Does Gymnema sylvestre extract prevent metabolic disorders in male C57BL/6J mice fed a high-fat diet?
Gymnema sylvestre extract demonstrates preventative effects against high-fat diet-induced metabolic disorders, including insulin resistance and liver steatosis, in a mouse model.
Kim et al. (2017) studied High-fat diet-induced metabolic disorders. Gymnema sylvestre (GS) extract vs. High-fat diet without GS was evaluated on Body weight, serum levels of lipid, insulin and leptin, adipose tissue, and liver inflammation. Gymnema sylvestre extract significantly suppressed the increase of body weight, serum lipids, insulin, leptin, and liver inflammation in mice fed a high-fat diet.